Since ancient times Ayurveda has played an essential role in treatment of disease as well as maintaining their healthy life by consuming natural herbs which are obtained from natural resources.Although ancient vedic were having many rapid and herbal solutions which they have also proposed in different smahitas with their detail remedies also they used to determine disease by pulse and tongue method which also gave them accurate prediction which they used to cured by their natural remedies where they got expertise in passing years. Moreover, ancient civilization followed this technique as it was not harmful and free from any side effect.
As,nowadays major society suffering from short term memory loss or long term memory loss.Also,many school going teens fails in memory boosting due to insufficient vitamins and minerals which are not consumed by them in their daily diet.This is observed in world throughout by different age group where many people consumes smoking,alcohol, drugs and unable to follow healthy diet due to busy lifestyle which do not give sufficient time to maintain their health.Also many research are also carried in universe by experts.However, they fails for accurate results for many medicinal products which are pursued as a memory enhancer.
WHICH PLANTS PARTS ARE USED AS A BRAIN BOOSTER
In pharmacology their are many natural herbs and their parts which are mentioned as a brain enhancer drugs.However,studied by scientist it is said that very few natural elements have proved and given 99% of the result.
Some of the plants which are used for increasing memory are bacopa monnieri, cumin,peppermint, ginkgo bilobo, rosemary oil, shankh pushpi and mandukaparni, ashwagandha.
This plants have different chemical composition which helps as a brain stimulation also it increase blood circulation as well as nerve impulse transmission.With the increase in blood circulation they also have other vitamins and minerals which forms the sheath and covering of the nerve as it make them strong for long term memory. This drugs have different parts which have different constituents where studies are carried out using it.
HOW DOES THE MEMORY ENHANCER DRUGS WORKS AS BRAIN STIMULATION
1.GENE EXPRESSION :-
One of the first mechanisms identified as critical for long-term memory consolidation is the requirement for de novo protein and RNA synthesis. Similar requirements have been found for long-term plasticity, including long-term facilitation in Aplysia californica and a phase of LTP that lasts more than one hour, known as late-LTP. Regardless, the findings that in addition to pharmacological approaches molecular and genetic methods have provided evidence that transcription and translation are essential for memory. from growth factor stimulation of tyrosine kinase receptors coupled to the activation of Ras and extracellular signal-regulated kinase (ERK); to G-Protein Coupled Receptor (GPCR) activation coupled to activation of adenylyl cyclase, increase in cAMP, and activation of protein kinase A (PKA); to the activation of stress pathways and glutamate release leading to release of intracellular calcium and relative downstream events. All of these pathways can lead to the activation of an activator form of CREB, CREB1. This activation in turn can lead to the transcriptional regulation of a number of target genes, including immediate early genes.
2.SYNAPTIC MODELING:–
Long-term memory formation is critically associated with synaptic remodeling, including the growth or pruning of synapses, as well as altered synaptic efficacy. These changes occur through a number of local regulations, including mRNA translation, protein degradation, remodeling of cytoskeleton, and receptor trafficking into and out of the synapse.One of the first transgenic manipulations that produced memory enhancement targeted receptor trafficking .NR2B subunit was overexpressed in prefrontal cortex, working memory tasks such as the T-maze and a modified water maze were also enhanced.Pharmacological studies indicated that manipulations of NMDA receptors (NMDARs) can enhance both working memory and LTM-consolidation suggesting that synaptic glutamate receptor expression and trafficking play a significant role in enhancing memory formation and maintenance. Enhancement via NMDARs can be obtained both with agonists and low doses of antagonists, suggesting that a tight regulation of NMDARs is required in order to facilitate memory processes.The memory enhancement effects after increasing NR2B that they may occur in part by the facilitation of LTP in these regions, whereas overexpression of an alternate subunit, NR2A, facilitates LTD, perhaps because NR2B containing NMDARs are more calcium permeable than NR2A-containing NMDARs.The ability for NR2B overexpression to result in memory enhancement may occur through the subsequent increased ability of NMDA receptors to be activated due to their increased number. Another critical receptor type that has been implicated in memory enhancement is the 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid (AMPA) receptor. Though, like NMDARs, AMPARs respond to glutamate, they do not have a magnesium block and are therefore activated with less depolarization of the cell.
3.NEUROMODULATION:–
Neuromodulators, which alter cellular and synaptic properties via widespread projections have a well-known role in memory function and many modulation pathways have been targeted for memory enhancement. In contrast with many other diseases of cognitive impairment, PD is specifically accompanied by deficits in tasks associated with prefrontal cortex, including executive function and planning, rather than with memory consolidation impairments. Dopamine is thus widely thought to be extremely important for working memory tasks relying on the prefrontal cortex (PFC), and low levels of dopamine receptor D1 (DRD1 or D1) antagonists enhance working memory as revealed by an increase in neuronal activity during a delay period of a delayed-non-match-to-sample task, whereas high levels of antagonists and agonists both impair that activity.
In addition to pharmacological approaches, there are a number of behavioral manipulations that have been found to be effective in promoting memory enhancement. First, repetition has long been known to enhance memory performance, and it has been consistently shown that repeated training or learning events are associated with better memory.Similarly, memory can be enhanced by targeting retrieval-induced reconsolidation, which occurs through repeated retrieval sessions.
studied has proved that consuming naturals herbs such as brahmi , ashwagandha, bacopa monnieiri for up to 40 days can initiate stimulation of memories boosting by giving a tremendous results for long term memories.
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